SERUM URIC ACID LEVEL IS AN IMPORTANT PROGNOSTIC MARKER IN NEURODEGENERATIVE DISEASES

Dr. Md. Raknuzzaman*, Tasnim Jannaty, Dr. Anis Ahmed, Dr. Md. Shahidullah, Dr. Md. Masud Rana, Professor, Shaikh Amir Hossain

ABSTRACT

Background: Neurodegenerative disease is a feature of many debilitating, incurable diseases that are rapidly rising in prevalence, such Alzheimer's, Parkinson's, prion, Huntington's, as amyotrophic lateral sclerosis (ALS) spinocerebellar ataxia(SCA), spinal muscular atrophy(SMA) and some other diseases or disorders. In contrast to many other disease states, low serum uric acid (UA) levels are found in many neurodegenerative diseases. Aim of the Study: The aim of this study was to evaluate the Serum Uric Acid Level as a prognostic marker in several neurodegenerative diseases. Materials and Methods: This study was carried out at neuromuscular disorder clinic, inpatient and outpatient Department of Neurology, Bangabandhu Sheik Mujib Medical University (BSMMU) Dhaka, Bangladesh. The duration of the study was from January 2018 to December 2018. This case-control cross-sectional study included 37 patients with several neurodegenerative diseases such as Alzheimer's disease (n=9), Parkinson's disease (n=8), prion disease (n=8), Huntington's disease (n=7) and finally amyotrophic lateral sclerosis (ALS) (n=5) were finalized as the case. On the other hand, 37 healthy people without any type of neurodegenerative or cerebrovascular disease met the proper exclusion criteria were recruited as the control group participants from stable outpatients and medical staff of the mentioned hospital. Results: In analyzing the Serum UA level we found the mean (±SD) Serum UA level of case and control groups were 4.66 ± 1.15 and 5.42 ± 1.20 respectively where the p-value was 0.0069 which indicated a significant correlation between both the groups. Besides this, in a specific analysis of the Serum UA level of only Alzheimer's patients, we found it was 4.58 ± 1.02. Although the number of Alzheimer's patients was 9, the p-value was 0.0377. So there was also significant. So Serum Uric Acid Level played an important role as a prognostic marker in several neurodegenerative diseases. Conclusions: Serum Uric Acid levels played an important role as a prognostic marker in several neurodegenerative diseases. The findings may be helpful in the diagnostic system of several neurodegenerative diseases.

Keywords: Serum Uric Acid Level, Neurodegenerative diseases, Alzheimer's.