EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ASSESSMENT OF HEMATOLOGICAL MARKERS USING THYMOQUINONE AS EXPERIMENTAL AND SILYMARIN AS STANDARD DRUG AGAINST HEPATIC INSULT CAUSED BY FIRST LINE ANTI TUBERCULOSIS DRUGS

Muhammad Waqas*, Shoaib Asif, Muhammad Masood, Zaman Hayat, Waqar Siddique, Farhan Asghar, Rabbia Tariq, Azka Musharaf and Imran Waheed

ABSTRACT

Gram negative rod Mycobacterium tuberculosis is the underlying causative agent for the progress of life threatening disease tuberculosis. First line antituberculosis drugs are main choice for physician to counter this dangerous disease, by producing promising effect to counter Mycobacterium tuberculosis, the selected group of drugs produce hepatotoxicity. In this study Thymoquinone, main constituent of Nigella sativa was used as experimental drug while silymarin as standard drug. The thymoquinone found to produce hepatoprotective effects in rabbits treated anti tuberculosis drugs. Thymoquinone showed remarkable result and persisted successful in achieving level of ALT, which is 17.09 (SD±1.39) close to the usual mean value of 18.96, results were found significant (P value < 0.005). Thymoquinone in both 40mg and 20 mg dose found effective but the result by TQ 40mg were extraordinary by achieving the level to (50.27 SD±5.88) very near to the normal mean level of (48.10) in contrast with standard drug silymarin (56.96 SD± 8.36). One more intense effect was observed on day 7, when TQ cut the value down from (54.18) on same day silymarin (70.00) was unable to change the level which prove the short onset of action of thymoquinone as compare to standard drug. P value < 0.005 were found statically significant.

Keywords: Mycobacterium Tuberculosis, Silymarin, Thymoquinone, ALT, AST.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing