FUNCTIONAL AND LABORATORY MARKERS IN STRATIFICATION OF THE RISK OF DEVELOPMENT OF CARDIOVASCULAR DISORDERS IN TEENAGERS WITH EXOGENOUS CONSTITUTIONAL OBESITY I DEGREE

*Khasanova Guzaliya and Agzamova Shoira

ABSTRACT

The results of studying the thickness of epicardial fat according to echocardiography, as well as a comparative analysis of plasma levels of adiponectin and highly sensitive C-reactive protein (CRPhs), as stratification factors for the risk of cardiovascular complications in adolescents with exogenous-constitutional obesity of the first degree, are presented. 20 adolescents with exogenously-constitutional obesity of the 1st degree, 10 adolescents with overweight and 10 practically healthy adolescents with normal weight were examined. The results of the study confirmed that an increase in CRPhs, hypoadiponectinemia, and an increase in epicardial fat deposition in adolescents with exogenously-constitutional obesity of degree I are risk factors for the development of cardiovascular complications. A negative correlation of blood adiponectin level with CRPhs concentration and epicardial fat deposition thickness confirms the anti-inflammatory properties of adiponectin and its protective effect on the development of cardiovascular complications associated with obesity.

Keywords: obesity, adolescents, highly sensitive CRPhs, adiponectin, epicardial fat thickness.