EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE CORRELATION BETWEEN TENASCIN-C AND SEX HORMONE LEVELS IN DEPRESSIVE PATIENTS: A POTENTIAL DIAGNOSTIC TOOL

Christian Cedric Bongolo*, Linzy Elton, Chelsea Fisher and Terence Olivier Ohoya Etsaka

ABSTRACT

Objective: The current research was performed to investigate the association between serum testosterone and Tenascin-C levels in people with depressive disease, and assess the potential significance of Tenascin-C as a predictive parameter for the assessment of depressive symptoms. Method: The levels of Tenascin-C were detected in the serum of 117 clinically depressive patients and matched 104 healthy blood donors by enzyme-linked immune-absorbance assay tests. Concentrations of estradiol, testosterone, free thyroxine, free triiodothyronine, thyroid-stimulating hormone and high-sensitivity C-reactive protein were also analyzed. Results: We found that patients with depression had lower levels of testosterone, free triiodothyronine, thyroid-stimulating hormone and testosterone/estradiol ratios than healthy controls, while Tenascin-C and hs-CRP levels were higher in patients compared with control subjects. The sensitivity of Tenascin-C in detecting depression was 83% at a specificity of 64%. Multiple linear regression analysis displayed that testosterone, testosterone/estradiol ratios and Tenascin-C levels were negatively correlated in male depressive patients. Increased Tenascin-C serum levels are associated with depression severity (p=0.003) and suicidal ideation (p=0.013). Conclusion: the progression of depressive disorder is potentially influenced by the up-regulation of TNC in the presence of low hormone concentrations in male patients.

Keywords: Tenascin-C; Sex hormone; Depression; Thyroid hormones.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 August 2020 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR AUGUST ISSUE PUBLISHED

    AUGUST 2020 Issue has been successfully launched on 1 August 2020.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing