EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECTS OF GASTRIC BYPASS ON NON-OBESE TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW AND META-ANALYSIS

*Dr. Mohamed Dahir Aden, Prof. Dr. Deng Tao

ABSTRACT

Objective: To assess the therapeutic effect of gastric bypass on non-obese type 2 diabetes mellitus (T2DM). Methods: Databases including PubMed, Web of Science, CNKI and Wan fang database were searched from 1985 to November 2016, and references of articles were also searched to collect randomized controlled trails or before-after self-controlled trails on gastric bypass in treating T2DM. We screened articles according to the predefined inclusion and exclusion criteria, extracted data, and evaluated quality of the included studies. Then meta-analyses were performed using RevcMan 5.2. Results: A total of 7 before-after self-controlled trials involving 230 patients were finally included. All these trials were graded as low quality, and all is three scores by Jadad scale. The results of meta-analysis showed that the therapeutic effect of gastric bypass on non-obese T2DM after twelve months treatment was good, There were significant reductions in both glycosylated hemoglobin[MD=-2.76,95%CI (-3.55,-1.97), P<0.00001] and fasting plasma glucose[MD=- 4.13,95%CI (-5.70,-2.56), P<0.00001], And the level of glycosylated hemoglobin to reduce postoperative twelve months after six months significantly[MD=0.27, 95% CI(0.05,0.49), P=0.02] the therapeutic effect of gastric bypass on non-obese T2DM after six months treatment was good. There were significant reductions in both glycosylated hemoglobin [MD=-2.78, 95%CI (-3.48,-2.08), P<0.00001] and fasting plasma glucose [MD=-4.62, 95% CI (-5.86,- 3.38), P<0.00001], the same time, the differences were statistically significant. Sensitivity analysis indicated that these results were stable, but funnel-plots indicated possible publication bias existed. Conclusion: The short-term therapeutic effect of gastric bypass on non-obese type 2 diabetes mellitus is better, medium-term curative effect is stable, but because of the small sample size into literature, methodological quality defects, still need to high quality, large sample and long-term follow-up studies to further verify the therapeutic effect.

Keywords: Type 2 diabetes mellitus; Gastric bypass; Non-obese; Systematic review; Meta- analysis.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing