EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

MEMORY ALTERATION AND POTENTIAL NON-ADDICTIVE EFFECTS INDUCED BY A CHRONIC INTAKE OF HOME MADE ALCOHOLIC DRINKING “ODONTOL”

AYISSI MBOMO Rigobert-Espoir*, TENE TADOUM Samuel Boris, NGUIDJOE Evrard Marcel, MOTO OKOMOLO Fleur Clarisse, NANGA Léopold Didier, NGOA MANGA Elisabeth Sylvie, NJAMNSHI KONGNYU Alfred

ABSTRACT

The last decade in Cameroon has been the seat of increased consumption of artisanal drinks including «Odontol». Appreciated by youngest and adults, this beverage has induced numerous deaths attributed to its poor manufacturing. Being in a context of emergency by 2035, this beverage of unknown composition and effects on human health still little explored. We have undertaken the study of possible addictive effects of «Odontol» as well as its effects on various essential functions for memory. Experimental analysis of behaviors associated with addiction and memory disorders in mice using various behavioral tests including conditioned place preference, object recognition and Y maze tests were performed. Results showed that the time spent in the «Odontol» associated compartment significantly decreases between the pre-conditioning and test (28.57%) in the conditioned place preference test, as well the time spent in the «Odontol» associated compartment compared to NaCl compartment during the test. In the object recognition test, animals of the test group spent less time exploring the new object than the control animals with a 57 times higher discrimination index when compared to test group animals. In the Y maze, test mice significantly spent less time (15.78%) in the new arm compared to control animal which spent 48.27% of time exploring the new arm. These results bring the light of possible aversion induced by «Odontol» and a severe attack of mnesic function in short and long term memories.

Keywords: Object recognition, Y maze, Conditioned preference place, aversion, memory.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing