EFFECT OF HYDRO ALCOHOLIC EXTRACT OF Oroxylum indicum linn AGAINST DIMETHYL BENZ [A] ANTHRACENE INDUCED MAMMARY GLAND TUMOUR IN FEMALE SPARGUE-DAWLEY RATS
Syed Ibrahim S. A.*, Rampriya A. R., Chidambaranathan N. and Nalini G.
The present study aimed that investigate the antitumor potential of Hydro alcoholic extract of Oroxylum indicum linn for 45 days against 7, 12-dimethyl Benz[a]anthracene (DMBA- 7.5mg/Kg) induced oxidative stress and mammary carcinogenesis in female spargue-dawley rats. The treatment protocol started from the day immediately after DMBA administration. Results obtained indicated that there was a significant elevation in the terms of tumour incident and tumour multiplicity in DMBA injected rats. The potential reduction in tumour volume was observed in treatment groups whereas treated with HAEOI reverse these changes. The activities of superoxide dismutase, catalase, and glutathione peroxidise (free radical scavengers) were found to be potentially higher in treatment groups when compared to toxic control. Histopathological examination revealed the formation of tumour in DMBA induced rats. Whereas treatment with extract significantly reduced the proliferation and replacement of normal ductular and alveolar structure of mammary gland. Therefore it can be concluded that the HAEOI was provided antioxidant defence, with strong anti-tumour activity against DMBA- induced mammary tumours.
Keywords: Breast cancer, Oroxylum indicum linn, DMBA.
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