EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF HYDRO ALCOHOLIC EXTRACT OF Oroxylum indicum linn AGAINST DIMETHYL BENZ [A] ANTHRACENE INDUCED MAMMARY GLAND TUMOUR IN FEMALE SPARGUE-DAWLEY RATS

Syed Ibrahim S. A.*, Rampriya A. R., Chidambaranathan N. and Nalini G.

ABSTRACT

The present study aimed that investigate the antitumor potential of Hydro alcoholic extract of Oroxylum indicum linn for 45 days against 7, 12-dimethyl Benz[a]anthracene (DMBA- 7.5mg/Kg) induced oxidative stress and mammary carcinogenesis in female spargue-dawley rats. The treatment protocol started from the day immediately after DMBA administration. Results obtained indicated that there was a significant elevation in the terms of tumour incident and tumour multiplicity in DMBA injected rats. The potential reduction in tumour volume was observed in treatment groups whereas treated with HAEOI reverse these changes. The activities of superoxide dismutase, catalase, and glutathione peroxidise (free radical scavengers) were found to be potentially higher in treatment groups when compared to toxic control. Histopathological examination revealed the formation of tumour in DMBA induced rats. Whereas treatment with extract significantly reduced the proliferation and replacement of normal ductular and alveolar structure of mammary gland. Therefore it can be concluded that the HAEOI was provided antioxidant defence, with strong anti-tumour activity against DMBA- induced mammary tumours.

Keywords: Breast cancer, Oroxylum indicum linn, DMBA.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )