EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PREVALENCE OF HIV, HCV, HBV INFECTION IN BLOOD DONORS DETECTED BY NUCLEIC ACID TESTING: AN INDIAN EXPERIENCE

Tulika Chandra MD*. Devisha Agarwal MBBS Scholar. and S.Nishat Fatima Rizvi PhD Scholar

ABSTRACT

Nucleic acid testing (NAT) is able to detect viruses during the ‘window period’ or the time between donor exposure to the virus and the appearance of antibodies. This allows for earlier detection of infection and further decreases the possibility of transmission via transfusion. Out of the 35,722 samples, 700 (1.95%) were reactive by ELISA. Discriminent assays found 40 (0.11%) to be reactive for HIV, 60 (0.16%) to be reactive for HCV and 600 (1.67%) forHBV. Apart from these reactive samples NAT was carried out on the non-reactive samples.Amongst them total of 158 (0.44%) were reactive for NAT. On discriminatory assays 2(0.005%) samples were reactive for HIV-1 and 2 also for HIV -2, 46 (0.12%) samples were reactive for HCV and 108 (0.30%) for HBV.NAT could detect HIV, HBV and HCV cases in blood donor samples that were undetected by serological tests. Third generation ELISA is the mandatory test in India. Our study confirms the utility of NAT and emphasizes the presence of HIV-2 in Indian donors. Study on such a huge population sample further questions the safety of blood supply by regular screening method and stresses on the introduction of NAT as a mandatory test by regulatory authorities.

Keywords: NAT, ELISA, HIV, HCV, HBV.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )