EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF SELENIUM AGAINST NALUFIN INDUCED MORPHOLOGICAL AND ENDO-SKELETAL ABNORMALITIES IN CHICK EMBRYOS

Marwa N. Atallah,*, Gamal M. Badawy, Islam M. El-Garawani, Fatma S. Abdallah, Hend T. El-Borm

ABSTRACT

Opioids administration during pregnancy can affect the embryonic development and can lead to different malformations in the developing embryo such as growth retardation, spontaneous abortion, skeletal defects and many limb deformities. The present study aimed to determinate the possible hazard effects of the new generation opioid pain killer nalufin on the morphology and endo-skeletal system of the developing chick embryo. Another aim was to investigate the ameliorative role of selenium on these effects. The fertilized eggs of leghorn chickens (Gallus gallus domesticus) were in ovo injected with 0.2ml of either nalufin (20mg/egg, single dose) or selenium (0.1 mg/kg, single dose) or combined injection. The injection of nalufin resulted in increased mortality rate and reduction in lengths and weights of embryos with many malformations including omphalocele, limb deformities, head enlargement, scanty feather, exencephaly, short beak and subcutaneous hemorrhage. Furthermore, nalufin led to many endo-skeletal malformations in the skull, vertebral column, ribs, pubis, limbs, incomplete ossifications of the bones and decreased length of the long bones. The co-injection of selenium ameliorated the mentioned malformations induced by nalufin.

Keywords: Chick embryo; Nalufin; Opioids; Selenium; Endoskeleton; Teratogenicity; Morphology; Embryology.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )