TO STUDY THE SUSTAINED EFFECT OF PROSTAGLANBIN INHIBITORS ON INTRAOCULAR PRESSURE IN NORMAL TENSION GLAUCOMA

*Dr. Shilpa Kulkarni (M.S., D.N.B., F.R.C.S.Ed)

ABSTRACT

AIM: To study the sustained effect of prostaglandin inhibiters on intraocular pressure in normal tension glaucoma. Methods: A retrospective study was done on 19 eyes of patients of Normal-tension glaucoma(NTG) for a period of 12 months. All patients were treated with once daily topical latanoprost.0.005%. Baseline IOP done by Goldman applanation tonometer were considered and mean IOP reduction were noted at 1,3,6,9,12 months in comparison to baseline mean IOP. Results: The mean baseline IOP was 16±2.98 mm Hg. There was a statistically significant reduction in mean IOP from the baseline in 1 month 2.86±0.2 mm Hg (p < 0.05) and after 12 months, the reduction was 2.94±0.2 mm Hg (p< 0.05). This shows a consistent reduction with once daily instillation of latanoprost. There was a significant higher reduction in intraocular pressures in patients with baseline IOP > 16 mm Hg as compared to patients with baseline IOP of < 16mm Hg (p <0.05). Conclusions: Latanoprost was found to be well tolerated and significantly reduced IOP in NTG patients along with sustained effect. IOP intraocular pressure, NTG normal- tension glaucoma, CCT central corneal thickness.

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