ENHANCEMENT OF SOLUBILITY OF VILAZODONE DRUG BY LIQUI-SOLID COMPACT TECHNIQUE

G. Y. Srawan Kumar*, R. B. Desireddy, P. Kasi Reddy, S. Saikrishna reddy, S. Durga Prasad and U. Naga Ravi

ABSTRACT

The aim of present work is to enhance the solubility rate of Vilazodone by using liqui-solid compacts. Liquisolid compacts were formulated using PEG 400 as a non volatile solvent along with avicel and aerosol as carrier and coating materials in R:2 ratio, by direct compression method. Totally nine formulations were formulated using different ratios of carrier to coating material, and the concentration of super disintegrant. Drug and Excipient compatability studies revealed that the drug and excipients were found to be compatable and there weren‟t any interactions between them. Prepared formulations were evaluated for pre-compression and post compression parameters. All the studies revealed that the all parameters were found to be in acceptable range for the Liquisolid compacts. From the in-vitro studies we can say that formulation F9 shows best drug release of 97.32% within 40 minutes where as all the other formulations takes about 50-60 minutes to release the drug. Based on the regression values it was concluded that the optimized formulation F9 follows First order kinetics.

Keywords: Vilazodone, FTIR, PEG 400, CCS, SSG, MCC and aerosol.