SYNTHESIS OF OCTAHYDROQUINAZOLINONE DERIVATIVES AND ITS ANTICANCER ACTIVITY EVALUATION
S. C. Jadhavara, H. M. Kasralikera, S. V. Goswamia, V. R. Choudharib and S. R. Bhusarea*
A convenient method was expanded for the synthesis of octahydroquinazolinones by one-pot reaction of a different salicylaldehyde, dimedone and urea/thiourea using [Hmim]HSO4 in catalytic amount. The synthesized derivatives were tested for inhibition of cancer cell. The primary analysis showed that number of synthesized molecules exhibited considerably admirable inhibition activities against MCF-7 human breast cancer cell.
Keywords: Anticancer activity, one-pot synthesis, salicylaldehyde, [Hmim]HSO4, Octahydroquinazolinones.
[Full Text Article]