EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF CIPROFLOXACIN COLON TARGETED TABLETS BY COMPRESSION COATING TECHNIQUE

T.J. Mohan Rao*, R.B. Desireddy, K. Krishna Reddy, K. Nagaraju, M. Pavan Kumar and M. Mahesh Reddy

ABSTRACT

The aim of the present study is to develop colon targeted drug delivery system for ciprofloxacin using various proportions of guargum and HPMC K4M to treat the crohn’s disease. The compression coated tablets of ciprofloxacin were prepared and were evaluated for hardness, thickness, friability, diameter, drug content, weight variation and invitro drug release studies. The amount of ciprofloxacin released from tablets at different time intervals was estimated by UV visible spectroscopy. From these evaluations it is observed that release of the drug was comparatively less in gastric and intestinal fluids and increased in colonic fluids. When the dissolution study was continued in simulated colonic fluids, the compression coated tablets with 175 mg of HPMC K4M coat released 96.07% (F8) and 99.02% (F9) of ciprofloxacin after degradation by colonic bacteria at the end of 24 h of the dissolution study. The compression coated tablets with 175mg of guar gum: HPMC K4M coat released about 98.09% (F14) of ciprofloxacin, respectively, in simulated colonic fluids indicating the susceptibility of the guar gum formulations to the rat caecal contents. The mean percentage of ciprofloxacin released at various time intervals was calculated and plotted against time. The mechanism of drug release with the formulations F8 and F9 was dominantly case-2 transport diffusion and followed zero order kinetics, where as the formulation F14 followed Korsemeyerpeppas equation.ciprofloxacin compression coated tablets showed no change either in physical appearance, drug content or in dissolution pattern. Based on the R² values obtained F9 is considered as the best formulation.

Keywords: Ciprofloxacin, Guar gum, HPMC, Crospovidone, Colon targeted drug delivery, Compression coating tech.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database