FORMULATION AND EVALUATION OF CIPROFLOXACIN COLON TARGETED TABLETS BY COMPRESSION COATING TECHNIQUE

T.J. Mohan Rao*, R.B. Desireddy, K. Krishna Reddy, K. Nagaraju, M. Pavan Kumar and M. Mahesh Reddy

ABSTRACT

The aim of the present study is to develop colon targeted drug delivery system for ciprofloxacin using various proportions of guargum and HPMC K4M to treat the crohn’s disease. The compression coated tablets of ciprofloxacin were prepared and were evaluated for hardness, thickness, friability, diameter, drug content, weight variation and invitro drug release studies. The amount of ciprofloxacin released from tablets at different time intervals was estimated by UV visible spectroscopy. From these evaluations it is observed that release of the drug was comparatively less in gastric and intestinal fluids and increased in colonic fluids. When the dissolution study was continued in simulated colonic fluids, the compression coated tablets with 175 mg of HPMC K4M coat released 96.07% (F8) and 99.02% (F9) of ciprofloxacin after degradation by colonic bacteria at the end of 24 h of the dissolution study. The compression coated tablets with 175mg of guar gum: HPMC K4M coat released about 98.09% (F14) of ciprofloxacin, respectively, in simulated colonic fluids indicating the susceptibility of the guar gum formulations to the rat caecal contents. The mean percentage of ciprofloxacin released at various time intervals was calculated and plotted against time. The mechanism of drug release with the formulations F8 and F9 was dominantly case-2 transport diffusion and followed zero order kinetics, where as the formulation F14 followed Korsemeyerpeppas equation.ciprofloxacin compression coated tablets showed no change either in physical appearance, drug content or in dissolution pattern. Based on the R² values obtained F9 is considered as the best formulation.

Keywords: Ciprofloxacin, Guar gum, HPMC, Crospovidone, Colon targeted drug delivery, Compression coating tech.