EVALUATION OF ANTI-CANCER ACTIVITY AND PHYTOCONSTITUENTS OF BIOPHYTUMSENSITIVUM LINN: AN INVITRO STUDY

Tharani M.*, Tamilselvan T., Ponnudurai K., Malaisamy N., Vignesh Mirthick R., Wafa Ahmed Saadeldin Badr and Sabari Murthy V.

ABSTRACT

Objective: In the current research phytochemical and invitro, anticancer activity was evaluated using petroleum ether extract and methanol extract of Biophytumsensitivum Linn. Materials and Methods: The whole plant was dried for fifteen days and grounded using mechanical blender. The extraction was carried out using the Soxhlet apparatus with 10 volumes of 75% Methanol and another extraction with Petroleum Ether (10 volumes of 75% solution). The extract was evaporated and dried. Preliminary phytochemical screening and FTIR techniques were performed to identify the basic components. Using DLA and EAC cell lines the anti-cancer activity was carried out. Results: The whole plant showed the presence of phenols and flavonoids at a higher rate than steroids, glycosides, and Ketones. Its presence was confirmed using FTIR reports. The cytotoxicity studies were highly significant in Methanol extract of Biophytumsensitivum Linn than Petroleum Ether extract. Conclusion: The effective anti-cancer activity was reported in the whole plant Methanolic extract of Biophytumsensitivum Linn as compared with petroleum ether extract. Further specific studies are required to find out the specific individual components.

Keywords: Biophytumsensitivum Linn, Phytochemical screening, DLA, EAC cell lines.