A REVIEW ON FAST DISSOLVING FILMS ALONG WITH THE METHODS OF PREPARATION AND THEIR ASSESSMENT CONSIDERATIONS
Kajol, Nikhil Saxena, Shubham, Ashish Kumar, Sujit Bose, Amneet Kaur*
Drug delivery plays an important role in delivering the main API to the targeted organ. The delivery of the drug depends on certain factors and one of the important factors is the ease of administration along with overcoming the first-pass metabolism of the drug. The oral route is having a loophole of the first-pass metabolism and to overcome this loophole, fast dissolving oral film (FDF) is an alternative route with respect to the conventional oral dosage form. The FDF can be consumed by pediatric, geriatric and dyphagic patients. The dosage form will give the complete bioavailability of the drug. The dosage form depends on the type of drug candidate, plasticizers, disintegrants, sweeteners, and flavoring agents. The main problem related to the FDF is not to incorporate the drug candidate which cannot withstand the buccal environment. There are several marketed forms that are available for the treatment of hypersensitivity, nausea, and acid reflux. The methods preferred for the preparation of the films are solvent casting, freeze-drying, etc. The main evaluation parameters for the films are disintegrating time, elongation property and wetting time.
Keywords: FDF, dyphagic, drug candidate, buccal, first-pass metabolism.
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