EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANALYTICAL AND BIOANALYTICAL PROFILE FOR ATORVASTATIN: AN EXPLORATORY REVIEW

R. M. Shroff, P. A. Bachhav, S. B. Ganorkar, A. A. Shirkhedkar* and S. S. Chalikwar

ABSTRACT

Statins are exceptional in lowering total cholesterol and low- density lipoproteins present in the human body. These are inhibitors of HMG CoA reductase; which are rate the limiting enzymes in Cholesterol biosynthesis. Atorvastatins used in the treatment of atherosclerosis and cardiac risks. Atorvastatin calcium is calcium salt of atorvastatin and a trihydrate. The atorvastatin is a medicine used to cure high cholesterol and marketed as calcium salt with the name Lipitor. Atorvastatin is generally combined with pharmaceutical formulations because they block the Niemann-Pick C1-Like protein cholesterol transporter and inhibit the absorption of cholesterol. The present review critically assesses various methods for the analysis of atorvastatin as well as atorvastatin calcium as bulk drug and pharmaceutical dosage forms and or in the biological fluid. This exhaustive review displays the assortment, correlation and assimilation of more than 80 analytical and bioanalytical approaches. These reported investigations are not limited to sophisticated chromatographic, spectrophotometric techniques but also literates about hyphenated stability-indicating analyses and its precise applications towards pharmaceutical estimation. The exhaustive tabular presentation of essential analytical information would be of great significance to pharmaceutical analysts. The compilation therefore explores the scope for comparison of the existing methods at once for better utility and effective future estimation.

Keywords: Atorvastatin Calcium, analytical, bioanalytical, statins.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database