ANALYTICAL AND BIOANALYTICAL PROFILE FOR ATORVASTATIN: AN EXPLORATORY REVIEW

R. M. Shroff, P. A. Bachhav, S. B. Ganorkar, A. A. Shirkhedkar* and S. S. Chalikwar

ABSTRACT

Statins are exceptional in lowering total cholesterol and low- density lipoproteins present in the human body. These are inhibitors of HMG CoA reductase; which are rate the limiting enzymes in Cholesterol biosynthesis. Atorvastatins used in the treatment of atherosclerosis and cardiac risks. Atorvastatin calcium is calcium salt of atorvastatin and a trihydrate. The atorvastatin is a medicine used to cure high cholesterol and marketed as calcium salt with the name Lipitor. Atorvastatin is generally combined with pharmaceutical formulations because they block the Niemann-Pick C1-Like protein cholesterol transporter and inhibit the absorption of cholesterol. The present review critically assesses various methods for the analysis of atorvastatin as well as atorvastatin calcium as bulk drug and pharmaceutical dosage forms and or in the biological fluid. This exhaustive review displays the assortment, correlation and assimilation of more than 80 analytical and bioanalytical approaches. These reported investigations are not limited to sophisticated chromatographic, spectrophotometric techniques but also literates about hyphenated stability-indicating analyses and its precise applications towards pharmaceutical estimation. The exhaustive tabular presentation of essential analytical information would be of great significance to pharmaceutical analysts. The compilation therefore explores the scope for comparison of the existing methods at once for better utility and effective future estimation.

Keywords: Atorvastatin Calcium, analytical, bioanalytical, statins.