A REVIEW ARTICLE ON THE POTENTIAL ROLE OF BOSWELLIC ACID IN PREVENTION AND TREATMENT OF CHRONIC AND INFLAMMATORY DISEASES
Nahala Thasnim P.*, Jasna K., Shiji Kumar P. S., Sirajudheen M. K., Nishad K. M.
Boswellic acids are pentacyclic triterpenes, Belongs to the active pharmacological compounds of oleo gum resin of different Boswellia species of the family Bursuraceae. Among the various boswellic acids,11-keto-beta-Boswellic acid (KBA) and acetyl-11-keto-beta-boswellic acid(AKBA) are pharmacologically active and potent inhibitors of 5-lipoxygenase.Animal experiments show the anti-inflammatory activity of the extract. The action is due to several mechanisms of boswellic acid, such as the inhibition of lipoxygenase and reduce the synthesis of prostaglandin. The pharmacological activity of boswellic acid was also evaluated by both preclinical and clinical studies. Boswellic acd is attributed to its ability to induce anti-inflammatory, expectorant, anxiolytic, analgesic, tranquilizing and anti-bacterial effects.
Keywords: Boswellic acid, acetyl-11-keto-beta-boswellic acid,11-keto-beta boswellic acid, chronic diseases, lipoxygenase, molecular targets, inflammation.
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