PREVALENCE OF CYTOMEGALOVIRUS ANTIBODIES AMONG PATIENTS WITH TYPE1 DIABETES MELLITUS IN ADEN CITY-YEMEN

*Abdul Rahman A. Humaid, Al-Ofairi B. A. and Al-Khaledi Y. S.

ABSTRACT

Cytomegalovirus (CMV) is an enveloped deoxyribonucleic acid (DNA) virus belongs to the herpes viruses family. It has been implicated as inducers Type1 diabetes mellitus (T1DM). The association between CMV and T1DM has been well described in the medical literatures. The study was a Case – Control and experimental combining the use of a structured questionnaire and analysis of serum samples obtained from 100 children (1- 19 years) who had history of TIDM as case group compared with 100 healthy children as control group in Al-madaen laboratories in Aden city, during the period from November 2016 to December 2017. The serum samples were analyzed for Immunoglobulin G (IgG) antibodies to CMV by Electro-Chemiluminescence Immunoassay (ECLIA). Sera of two hundred (200) of children were collected. The samples were tested for anti-cytomegalovirus IgG, 69 (34.5%) of the total children of study were sero-positive CMV IgG, 13 (13%) of sero-positive CMV IgG were non-diabetic children (control group), while most of them, 43 (21.5%) were diabetic children which represent the case group, the results indicate association (P-value 0.011) of CMV IgG antibody with TIDM in children. The seroprevalence of CMV antibodies among children (1- 19 years) in Aden City, Yemen is slightly high 69 (34.5%), and the study reveals significant relationship of CMV IgG antibodies with TIDM in children.

Keywords: Prevalence, Cytomegalovirus (CMV), Type 1 diabetic mellitus (TIDM), Aden, Yemen.