A REVIEW ARTICLE ON OPHTHALMIC INSERTS

Noora Thasni*, R. V. Celestin Baboo, Shiji Kumar P. S., Sirajudheen M. K. and Sherin A.

ABSTRACT

Administering drugs to the eyes is one of the most challenging tasks that pharmacists face. The main barriers to eye medication are the ability to maintain a therapeutic level of the drug at the site of action over a long period of time. The ophthalmic preparations are available as a sterile, buffered isotonic solution. Different types of dosage forms are used as a delivery system for eye delivery of drugs. The most commonly prescribed dosage form is the eye drop solution because drops are easier to administer. Suspensions, gelled systems and ointments are also used to extend the therapeutic effect. The properties of eye preparations should not irritate the eye tissue. Homogeneous, i.e. Particles that are evenly distributed smooth and free of lumps or agglomerates. Relatively non-greasy. Shouldn't cause blurry vision. Should not cause an unbearable feeling of foreign bodies. Sterile and sufficiently preserved. Physically and chemically stable. Effective. New systems for administering medicinal products to the eye: The administration of medicinal products with eye drops requires frequent use. Prolonged drug release can be achieved with ophthalmic inserts with fixed devices placed in the eye. However, the inserts must be removed when they are no longer needed. Ocuserts are the new drug delivery systems designed to release the drug at predetermined and predictable rates, eliminating the need for frequent drug delivery. The systems generally include bio-erodible implantable elements with controlled, delayed and / or delayed release with multiple layers of different materials and / or different material concentrations. The elements generally comprise an inner layer or core containing a therapeutic agent and one or more outer layers made of polymeric materials, for example essentially pure polymeric materials. Important efforts in the area of topical eye administration relate to the design and conception of new ophthalmic drug delivery systems that can extend.

Keywords: Bio erodible, diffusion membrane, ocular inserts.