3D PRINTING TECHNOLOGY FOR TABLETS: OPPORTUNITIES & CHALLENGES
Rameesha N. K.*, Sirajudheen M. K., Shiji Kumar P. S. and Sherin A.
ABSTRACT
The 3D printing has a role in medical devices industry & pharmaceutical industry due to its application on various channels of health care industry. It has become one of the most revolutionary & powerful tool serving as a technology of precise manufacturing of individually developed dosage forms, tissue engineering & disease modeling. This technology exist for a long time it is of public interest highly now due to the approval of 3D printed tablet, other medical devices & also with the arrival of USFDA‘s guidance on technical considerations specific to devices using additive manufacturing with possess 3D printing has triggered many thoughts about this technology which needs to be considered for successful delivery of intended product. This review summarizes the newest achievement & challengers of additive manufacturing in the field of pharmaceutical & biomedical research that have been published since 2015. Currently developed techniques of 3D printing are briefly described while extensive analysis of extrusion – based methods as the most intensively investigated is provided. And also this paper presents regulatory agencies expectations, limitations, problems in establishing such setups in production of drug products, advantages, disadvantages, applications, methods and associated risks involved in manufacturing. The issue of printlets attributes,I.e. shape & size is described with regard to personalized dosage forms and medical devices manufacturing. The undeniable benefit of 3D printing are highlighted, however a critical view resulting from the limitation & challenges of the additive manufacturing is also included. It provides the extensive review of the current status of research and development on this platform. As well as the regulatory issue is pointed.
Keywords: 3d printing, FDM method, Spritam.
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