EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIDIABETIC ACTIVITY OF POLYHERBAL FORMULATION CONTAINING CITRULLUS COLOCYNTHIS, PIPER NIGRUM, ASPARAGUS RACEMOSUS, CINNAMOMUM TAMALA (CPAC) IN ALLOXAN INDUCED DIABETIC RATS

Prof. Pavan Folane*, Shrikrushna Unhale, Purva Kale, Snehal Shelke and Prof. Suraj Sagrule

ABSTRACT

The aim of the present study was to evaluate the antidiabetic activity of polyherbal formulation containing Citrullus colocynthis, piper nigrum, Asparagus racemomusin, and Cinnamomum tamala alloxan induced diabetic rats. The polyherbal CPAC, is one of such herbal remedies prepared from the fruit of Citrullus colocynthis, seeds of piper nigrum, roots of Asparagus Racemomus and leaves of Cinnamomum Tamala used to evaluate antidiabetic activity. The dose of the formulation was determined from acute toxicity study. The polyherbal formulation of CPAC had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. The antidiabetic effect of polyherbal formulation was studied in Alloxan (120mg/kg b.w., i.p.) induced diabetes in male wistar rats for doses 200 mg/kg b.w. and 400 mg/kg b.w. (p.o.) daily for 21 days, and the effect was compared with oral dose of 5mg/kg, b.w. glibenclamide. The administration of extracts were continued for 21 days was evaluated through the estimation of HDL, LDL, VLDL levels, SGPT and SGOT levels, Total cholesterol levels and Total triglycerides levels. Blood samples were collected through the tail vein on days 1, 7, 14 and 21 after drug administration and the blood glucose levels were estimated using Accu-check glucometer. Diabetes caused by Alloxan treatment increases the level of glucose and biochemical parameter in blood sample but treatment with polyherbal formulation, protects from diabetes and significant decrease the elevated glucose, LDL, VLDL levels, SGPT and SGOT levels, Total cholesterol levels and Total triglycerides levels, increased in HDL level.

Keywords: Polyherbal Formulation, Alloxan, Glibenclamide, Tween 80 (5%), Ethanol, Hexane, 5% Glucose.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )