IN-VITRO ANTIOXIDANT STUDY OF LYOPHILIZED EXTRACT OF NILAVEMBU KUDINEER CHOORANAM– A TRADITIONAL SIDDHA FORMULATION
Abinesh Raj, D. Anusha*, K. Punnagai and D. Chamundeeswari
Nilavembu kudineer chooranam (NVK) is a traditional Siddha poly herbal formulation controls all types of fever associated with body ache. It exhibits potent antiviral activity against viruses causing Dengue and Chikungunya fever. In fevers associated with inflammatory conditions such as abscess it counteracts the inflammation and reduces body temperature. several studies have established that oxidative stress as a determinant of vascular homeostasis besides its involvement in the pathogenesis of various infectious diseases, such as chronic hepatitis C, Japanese encephalitis, leptospirosis, respiratory syncytial virus-induced acute lung inflammation, malaria, chagas cardiomyopathy, schistosomiasis, sepsis, acute herpes simplex virus type 1, measles subacute sclerosing panencephalitis, and dengue. Literature revealed that no antioxidant studies have been carried out in this traditional formulation. So in the present study the antioxidant potential of lyophilized extract of NVK was evaluated using different methods such as DPPH, nitric oxide free radical scavenging assay and FRAP reducing power assay. The results revealed that significant free radical scavenging activity was observed with NVK in DPPH and Nitric oxide free radical scavenging assay methods. The NVK exhibited potent antioxidant power in FRAP assay.
Keywords: Nilavembu kudineer chooranam, DPPH assay, FRAP reducing power assay, Nitric oxide assay, Antioxidant property.
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