EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

STUDY OF ADVERSE DRUG REACTIONS PROFILE IN A TERTIARY CARE HOSPITAL: A RETROSPECTIVE OBSERVATIONAL STUDY

Sahana M. Mogali, Aruna Bhushan* and Md. Ajmat Khan

ABSTRACT

Objective: To study adverse drug reactions (ADRs) profile in a tertiary care hospital and to determine seriousness, predictability, causality, severity and outcome of ADRs. Method: A retrospective observational study was conducted in a tertiary care hospital over a period of five years. Recorded data was collected from various department regarding details of patients, drugs, ADRs and entered in a proforma. It was evaluated using appropriate scales. Simple descriptive statistics was used for analysis. Results: Total number of ADRs reported in five years were 410. As per criteria 330 ADRs were included and analyzed out of which female patients were 217 (65.76%) and males 113 (34.24%). Majority of patients were in age group of 21 to 50 years (69.7%). Among these reactions 29 (8.78%) were serious and 301 (91.21%) non-serious. Maximum ADRs reported from medicine department 188 (56.9%). Cutaneous ADRs were most frequent 134 (40.6%). Antiretroviral agents were most common drugs causing 80 (24.2%) ADRs. Overall predictability was 69.7%. When causality assessment was done 2 (0.6%) ADRs were certain, 121 (36.7%) probable and 207 (62.7%) possible. Severity assessment showed 129 (39.1%) reactions were mild, 201 (60.9%) moderate and none in severe grade. Outcome was 256 (77.6%) patients had recovered, 69 (21%) were recovering and 2 (0.6%) had not recovered from ADR. Conclusion: Most of ADRs in our study was due to polypharmacy. Due to these ADRs there is prolonged hospitalization and increase in economic burden. Hence there is always a need for prevention and periodical monitoring of ADRs.

Keywords: Adverse drug reactions, causality assessment, severity.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )