THE IMMUNE SYSTEM INDICATOR FEATURES OF PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS

Kaypbekova G. K. and Musakhodjaeva D. A.*

ABSTRACT

Background: It has been established that JRA is a multifactorial disease, the pathogenesis of which is very complex and is largely insufficiently studied. Based on the modern concepts, one of the key links in the development of the pathological process in rheumatoid arthritis is the dysfunction of the immune system. Objective: 53 children with juvenile rheumatoid arthritis were taken a clinical and immunological examination. Methods: We studied a concentration of circulating immune complexes (CIC), phagocytic activity, and the level of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6) among the children with various forms of the disease depending on the duration of the course of JRA. Result: It was revealed that the children with the juvenile disease are characterized by changes in indicators of innate immunity and cytokine status. Probably, these changes are associated in the active phase of the disease with a bright protective reaction of the body, and with prolonged antigenic stimulation, with a depletion of the functional activity of the immune system. Conclusion: Summarizing the foregoing, we can conclude that among the children with juvenile deformity there is a desynchronization of the immune system what is manifested in the increased secretion of pro-inflammatory cytokines. The most pronounced disorders are observed among the patients with a systemic form of the disease accompanied by a visual activity of the pathological process and depending on the duration of the disease.

Keywords: Children, rheumatoid arthritis, immune status.