EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE IMMUNE SYSTEM INDICATOR FEATURES OF PATIENTS WITH JUVENILE RHEUMATOID ARTHRITIS

Kaypbekova G. K. and Musakhodjaeva D. A.*

ABSTRACT

Background: It has been established that JRA is a multifactorial disease, the pathogenesis of which is very complex and is largely insufficiently studied. Based on the modern concepts, one of the key links in the development of the pathological process in rheumatoid arthritis is the dysfunction of the immune system. Objective: 53 children with juvenile rheumatoid arthritis were taken a clinical and immunological examination. Methods: We studied a concentration of circulating immune complexes (CIC), phagocytic activity, and the level of pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6) among the children with various forms of the disease depending on the duration of the course of JRA. Result: It was revealed that the children with the juvenile disease are characterized by changes in indicators of innate immunity and cytokine status. Probably, these changes are associated in the active phase of the disease with a bright protective reaction of the body, and with prolonged antigenic stimulation, with a depletion of the functional activity of the immune system. Conclusion: Summarizing the foregoing, we can conclude that among the children with juvenile deformity there is a desynchronization of the immune system what is manifested in the increased secretion of pro-inflammatory cytokines. The most pronounced disorders are observed among the patients with a systemic form of the disease accompanied by a visual activity of the pathological process and depending on the duration of the disease.

Keywords: Children, rheumatoid arthritis, immune status.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )