EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

FEATURES OF REPRODUCTIVE DISORDERS IN WOMEN WITH HYPOTHYROIDISM AND HYPERTHYROIDISIS

*A. L. Amilova, G. D. Narimova and H. K. Nasyrova

ABSTRACT

This article examined the features of the problems of the relationship of reproductive disorders in women of reproductive age with thyroid gland pathologies. Material and methods. 220 women of reproductive age were examined, of which 78 (35.4%) were taken for research with various reproductive disorders. Patients were divided into 2 groups depending on the hormonal activity of the thyroid gland. Group 1 (33) of patients with hypothyroidism of various etiologies and group 2 (45) of patients with hyperthyroidism. The complex of laboratory and clinical examinations included: anamnesis, examination; clinical and biochemical research methods; a study in the blood plasma of hormones (thyroid stimulating hormone (TSH), prolactin, St.T3, St. T 4, antibodies to thyroid peroxidase (AT-TPO); luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, progesterone, testosterone); ultrasound of the thyroid gland (thyroid gland), mammary glands, pelvic organs; fine needle thyroid biopsy, pituitary MRI. The aim of the study was to study the features of the problems of the relationship of reproductive disorders in women of childbearing age with thyroid gland pathologies. Results. A comparative analysis of various pathologies of reproductive function in both clinical groups showed that menstrual dysfunction in the first clinical group was dominated by oligomenorrhea - 30%, and in the second group, opsenomenorrhea - 24% and dysmenorrhea-24.4%. In women with hypothyroidism (12%), I degree galactorrhea was detected. In the second group, pathology of the cervix was detected in 27% with a predominance of pseudo-erosion (33.3%), and in 12.5% - uterine fibroids. The presence of chronic salpingoophoritis was detected in 47.5%, cystic changes in the ovaries in 27% of women of the first clinical group. Conclusions. In women with a deficiency of thyroid hormones, a decrease in the pituitary gonadotropic function occurs with the development of hyperprolactinemia, a decrease in steroidogenesis, and a deficiency of the luteal phase of the menstrual cycle. With hyperthyroidism in women, hyperestrogenism is observed, which, according to the feedback mechanism, leads to a decrease in the concentration of FSH. At the same time, the level of progesterone remains quite low due to a decrease in the sensitivity of ovarian tissues to luteinizing hormone in conditions of FSH deficiency.

Keywords: Thyroid gland, reproductive disorders, hormonal changes.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )