A CLINICAL STUDY TO EVALUATE THE EFFICACY & SAFETY OF CURCUVAIL IN PATIENT WITH CHRONIC JOINT PAIN (RHEUMATOID ARTHRITIS)

Dr. Harisha. S, Director*

ABSTRACT

Background: Rheumatoid Arthritis is a systemic inflammatory and destructive joint disease with a prevalence of about 1–2% of the adult population worldwide. Rheumatoid Arthritis (RA) is an autoimmune disease that can cause joint pain and damage throughout body. It typically results in warm, swollen, and painful joints. The major goal of Rheumatoid Arthritis treatment is to reduce joint pain induced by inflammation in the joints, daily wear and tear of joints, and muscle strains. The existing pharmaceuticals for treating Rheumatoid Arthritis are analgesics, steroids, and non-steroidal anti-inflammatory drugs (NSAIDs), which reduce the symptoms such as severe pain and inflammation. Classical NSAIDs are cyclooxygenase (COX) inhibitors that inhibit prostaglandin and thromboxane synthesis, thereby reducing inflammation. New NSAIDs selectively inhibit COX-2 and are usually specific to inflamed tissue, which decreases the risk of peptic ulcer. The Curcuminoid are natural phenols that are responsible for the yellow color of turmeric. Curcumin can exist in several tautomeric forms, including a 1, 3-diketo form and two equivalent enol forms. The present study is conducted to evaluate safety and efficacy of Curcumin in Patients with Chronic joint pain (Rheumatoid Arthritis). Objectives: To assess the efficacy and safety of Curcumin in Patients with Chronic joint pain (Rheumatoid Arthritis). Conclusion: The study concludes that, TEST -CURCUVAIL (CURCUMIN) due to its anti-inflammatory and immunomodulatory effect it is more efficacious and safer in comparison to PLACEBO (B) in treatment of chronic joint pain due to rheumatoid arthritis.

Keywords: non-steroidal anti-inflammatory drugs (NSAIDs), Rheumatoid Arthritis (RA) and cyclooxygenase (COX).