SYNTHESIS OF SOME DIHYDROPYRIMIDINE DERIVATIVES CARRYING 1,3,4-OXADIAZOLE MOIETY AS ANTICANCER AGENTS

Shada H. Yassin, Tawfeek A. Yahya* and Jalal H. Abdullah

ABSTRACT

A series of dihydropyrimidines (4a-d) were synthesized by reaction of 3,4-dihydropyrimidine-2(1H)-thione (3a-d) with 2-(chloromethyl)-5-chlorophenyl-1,3,4-oxadiazole. The compound 4b showed the highest anticancer activity (IC50= 28.2 µM) when compared to standard drug doxorubicin (IC50= 36.3 µM).

Keywords: Chalcone, Dihydropyrimidine, 1,3,4-Oxadiazole, HEPG2, Anticancer.