( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Eyaufe A. A. O.,* Esumeh F. I., Osagie R. N., Adeniran K., Alikah S., Festus O. O., Iserhienihien O., Unuabonah F. H. and Okodua M. A.


This study assesses BCG uptake by determining quantitatively TNF alpha levels pre(before BCG was administered) and post BCG vaccination(six weeks after BCG was administered). The cytokine, tumor necrosis factor alpha (TNFα) plays a paramount role in curtailing infection by Mycobacterium tuberculosis, the causative agent of tuberculosis in humans. M. tuberculosis can counter this TNFα based defense by decreasing host cell TNF production. Three hundred and seventy three serum samples were analyzed for TNF α using the human TNF ELISA kit (Boster Biological Technology Co. Ltd, USA). In Irrua, 191 samples (130 pre- BCG vaccination and 61 post-vaccination) were analyzed, while in Asaba, 182 samples (120 pre-BCG vaccination and 62 post BCG vaccination) were analyzed. In Asaba, TNFα levels was the same pre-BCG vaccination in both centres. Post vaccination, TNFα levels in Asaba was significantly higher (P < 0.05). There was no significant difference in TNFα levels of male and female infants pre and post BCG vaccinations. There was weak correlation between age and TNF alpha levels. The decrease in TNF levels post BCG vaccination reveals that, the vaccine did not enhance TNFα levels, which is crucial in Mycobacterium tuberculosis infection. Thus it is necessary to develop tuberculosis vaccines that can enhance TNFα production. This study also shows that in neonates, age and gender did not affect TNF alpha response.

Keywords: TNF?, BCG, Neonates.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on


    NOVEMBER Issue has been successfully launched on 1 November 2021.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )