THE CLINICAL COURSE OF JUVENILE RHEUMATOID ARTHRITIS OF THE CHILDREN FROM THE ADVERSE RESIDENCE AREA

*Kaypbekova G. K. and Musadjanova L. Kh.

ABSTRACT

Background: According to the results of various studies, prevalence of JRA is from 2 to 19 cases per year per 100,000 of the population, and frequency of the disease varies in different ethnic groups, in connection with which a genetic predisposition is assumed in etiology of this pathology, as well as influence of environmental factors, such as climatic-environmental and geographical conditions Objective: to achieve this goal dynamic observation data were analyzed including the results of a complex examination of 315 children with JRA at the age of 7-16. Result: The risk factors contributing to occurrence of juvenile idiopathic arthritis include: a burden of a family history of rheumatic diseases; a complicated obstetric and gynecological history of a mother; a pathology of pregnancy and childbirth; early conversion to artificial feeding; frequent infectious morbidity preceding development of juvenile idiopathic arthritis. The clinical picture of children with JRA living in an environmentally favorable region was different from that of children living in an unfavorable region by the course nature of the disease. Juvenile rheumatoid arthritis of children from an unfavorable region was characterized by torpidity, a tendency to persistence and prevalence of a pathological process.

Keywords: Juvenile rheumatoid arthritis (JRA), clinic, risk factors, ecology.