GLOMERULAR FILTRATION RATE OF HUMAN IMMUNODEFIENCY VIRUS (HIV) PATIENTS ATTENDING HIV CLINIC AT BENUE STATE UNIVERSITY TEACHING HOSPITAL, MAKURDI, NIGERIA

Monday O. Ogiator*, Joseph E. Ojobi, Ochoche O. Ijachi and Matthew Okpe

ABSTRACT

Background: Glomerular disease with proteinuria and renal failure are common complications of human immunodeficiency virus (HIV) infection. Human immunodeficiency virus (HIV) – related renal diseases are important causes of end stage renal disease in Africa. HIV positive individuals are routinely screened for creatinine and urea levels in HIV clinics in Nigeria but glomerular filtration rate is not routinely calculated and as a result early renal dysfunction is usually missed. We aimed to estimate the glomerular filtration rate (GFR) of HIV positive individuals seen at the HIV clinic of Benue State University Teaching Hospital (BSUTH), Makurdi, Nigeria. Objectives: To determine the glomerular filtration rate of HIV positive individuals attending HIV clinic at BSUTH, Makurdi Nigeria Method: One Hundred and fifty two HIV positive individuals attending HIV clinic and 65 age and sex matched HIV sero-negative individuals (controls) from Medical Outpatient Department were recruited. Result: Forty three (28.3%) of HIV positive individuals attending had estimated GFR ≤ 60mLs/minute compared to 5(7.7%) of HIV sero-negative individuals (control). The result was statistically significant. Conclusion: There is high prevalence of HIV positive individuals with renal insufficiency attending HIV clinic at BSUTH. This finding emphasizes the need for routine estimation of GFR of HIV positive individuals.

Keywords: Glomerular Filtration Rate, Human Immunodeficiency Virus, End Stage Renal Disease.