EVALUATION OF ANTIDIABETIC ACTIVITY OF SWERTIA CHIRAYITA AND PANAX GINSENG
*Samreen Begum, Dr. A. Srinivasa Rao and M. Sri Ramachandra
Diabetes mellitus, one of the most common endocrine disorders has caused significant morbidity and mortality due to macro vascular and micro vascular complications. Currently available therapies for diabetes include insulin and various oral anti diabetic drugs have number of serious adverse effect; therefore the search for more effective and safer hypoglycemic agents is one of the important areas of investigation. Some medicinal plants have been reported to be useful in diabetes worldwide. The herbs like swertia chirayata shown to protect the liver. It contains xanthones which is reputedly effective against Malaria, Tuberculosis. It also cures constipation and used for treating dyspepsia with all other properties the swertia chirayita shows good anti diabetic activity. The other herb which was used to carry out the experiment panax ginseng is well effective in case of anti-sterility in men, it prevents cancer and fight chemical dependency (anti proliferative). The study was conducted to examine the possible antidiabetic activity of swertia chirayata and panax ginseng leaf extraction on male wistar rats. Gold thio glucose method was used to induce diabetes in rats. Initially blood glucose levels were increased abruptly after induction. After giving the oral administration of ethanolic extract of swertia chirayat (100mg/ Kg, 200mg/kg) and panax gingseng (250mg/kg, 100mg/kg). Finding of this research showed that ethanolic extract of a plant swertia possess phytochemicals like steroids, alkaloids, tannins, flavonoids and panax ginseng possess alkaloids, carbohydrates, flavonoids and tannins significant (P< 0.05) anti diabetic activity. The results were compared with standard drug metformin (400mg/kg).
Keywords: Swertia chirayita, panax ginseng, Antidiabetics.
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