EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

PYCNOGENOL AND TALBINAH CAN AMELIORATE THE ANTIDEPRESSANT EFFECT OF DESVENLAFAXINE IN DEPRESSION-LIKE BEHAVIOR IN MICE

Eman Zakareya Abdelaziz*

ABSTRACT

This work was designed to investigate the possible antidepressant effects of pycnogenol and talbinah as monotherapy or in combination with desvenlafaxine (DV) in the socially isolated male mice for 4 weeks before the experiment to induce depression model. We used 70 mice divided into 7 groups (10 mice per each).Group I: Normal control group that receive only distilled water, Group II: the diseased control group, Group III: pycnogenol (PYC), Group IV: talbinah, Group V: DV (10 mg/kg, p.o.), Group VI: PYC + DV, Group VII: talbinah + DV. Forced swimming test (FST), tail suspension test (TST), and water finding test were carried out at the end of the 4 weeks of treatment. Social isolation induced depressive-like behaviors as observed by increased immobility time in the FST and TST. Also, it induced decreased learning performance as observed by increased water finding test. The administration of DV, talbinah and pycnogenol alone was able to reverse the increases in the immobility time and water finding test. The combination of pycnogenol / or talbinah and DV potentiated the observed effects of DV. These results suggest that augmentation therapy with the addition of a source of tryptophan as talbinah or an antioxidant drugs as PYC may be an important pharmacological approach for the treatment of depression.

Keywords: talbinah, barley, pycnogenol, desvenlafaxine and depression.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )