( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



*Dr. C. Sumalata, Dr. G. Rajeswari, Dr. Jaya Krishna and Dr. Sneha Shukla


Background: Gynaecomastia, a glandular enlargement of breast in males, due to Anti-Tubercular drugs is a very rare entity. There had been few studies showing isoniazid, ethambutol and thioacetazone are the drugs causing gynaecomastia. We present a case where gynaecomastia was seen in male patient after intake of isoniazid as part of treatment of tuberculosis. Case Report: A 31 year old man was diagnosed pulmonary tuberculosis, after doing sputum smear microscopy. After taking 3 months of Anti tuberculosis drugs, the patient felt swelling in Breast region presenting as painless bilateral gynaecomastia. Physical examination of external genitalia no abnormality and all secondary sexual characteristics were intact. Isoniazid was suspected as the reason for gynaecomastia and it was stopped. Consequently the breast swelling reduced, patient was reassured and Isoniazid was restarted to complete the treatment. Discussion: Adverse drug event management is a very important during the course of Anti tuberculosis therapy. In the above case, the gynaecomastia or the pain was subsided after stopping of the suspected drug. Gynaecomastia related to use of Isoniazid was first recognized in1953. The mechanism of Isoniazid causing Gynaecomastia is not known. The plausible proposed mechanism is altered androgen-estrogen balance due to disturbance in pyridoxine metabolism. Defective androgen receptors may also contribute to Gynaecomastia. Other mechanisms might be refeeding Gynaecomastia which is caused by restoration of weight, Gonadotrophin secretion and gonadal function.

Keywords: Isoniazid, gynaecomastia, Anti tubercular drug.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on


    NOVEMBER Issue has been successfully launched on 1 November 2021.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )