ANTIDIABETIC ACTIVITY OF AQUEOUS EXTRACT OF CAESALPINIA BONDUCELLA LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC RATS
*Dr. Vijay Patel M. Pharm., Ph.D. and Meena Joshi M. Pharm.
The aim of present study was to evaluate the antidiabetic activity of aqueous extract of Caesalpinia bonducella leaves in Streptozotocin induced diabetic rats. The extract was obtained by cold maceration process and the animals were induced diabetes by single dose streptozotocin method. A comparison was made between the action of different concentration of leaves extracts of Caesalpinia bonducella in a dose of 100 and 200 mg/kg of body wt. and a known antidiabetic drug glibenclamide (4mg). Results shows successive decline in blood glucose level in diabetic animal. Antioxidants have been reported to prevent oxidative damage caused by free radical and may prevent the body from various diseases. The enzymatic antioxidants like catalase, superoxide dismutase have also been evaluated in the aqueous leaves extracts of Caesalpinia bonducella they were found to be the good sources of natural antioxidants and can be useful in treating the diseases associated with oxidative stress.
Keywords: Caesalpinia bonducella, Antidiabetic activity, Antioxidant, Streptozotocin, Superoxide dismutase, Catalase.
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