LEAD ACETATE INDUCED TOXICITY ON LIPID METABOLITES IN DIFFERENT PARTS OF DANIO RERIO (ZEBRA FISH)

Syeda Viquar Unnisa, Dr. Ghousia Begum*, Khwaja Amtul Raouf Qazi

ABSTRACT

Aquatic toxicology refers to impact of natural materials and manufactured chemicals on marine sources. Metal contamination is widely spread particularly in regions influenced by anthropogenic and industrial activities. The acute toxicity study (LC50) of lead acetate to Danio rerio (zebrafish) at 96 hrs is determined as 354.8 ppm. The sub – lethal concentration 118.26 ppm of lead acetate is selected to carry out the biochemical estimations in tissues of zebrafish for 4 days by using standard methods. The results of the study indicated decrease in total lipids and increase in free fatty acid and cholesterol in gills, viscera and body of fish. The behavioral patterns such as irregular, erratic jerky swimming movement around the experimental aquaria, followed by drowning down has been observed during the exposure period. Therefore, measurement of biochemical parameter is considered to be significant tool in toxicology to diagnose the health status of fishes in the aquatic ecosystem.

Keywords: Aquatic toxicology, lead acetate, Danio rerio, LC50, biochemical parameters.