SYNTHESIS OF QUINOLONE DERIVATIVES SHOWING ANTIFUNGAL ACTIVITY

Syeda Saniya Fatima*, Syeda Wasfiya Noor, Afreen Begum and Imam Pasha Syed

ABSTRACT

We have synthesized a few novel quinoline analogs combining with distinctive substituted fragrant and hetero cyclic aldehydes ring structure to obtain some better antifungal agents. We have successfully synthesized five derivatives from quinoline compound as qd1, qd2, qd3, qd4, qd5 and thier IUPAC names are. a) N-benzylidene-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)- yl)benzenesulfonamide. b) N-benzylidene-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)-N-(4- methoxybenzylidene) benzenesulfonamide. c) N-benzylidene-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)-N-(3- methoxybenzylidene) benzenesulfonamide. d) N-(2-hydroxybenzylidene)-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)- yl)benzenesulfonamide. e) N-{2-[(1E)-3-oxoprop-1-en-1-yl]benzylidene}-4-(7-hydroxy-4-methyl-2- oxoquinolin-1(2H)-yl)benzenesulfonamide. This work aims to outline the recent advances in quinolone derivatives showing excellent antifungal activity equipped with conventional drugs. This review covers the recent advances in quinolone derivatives as potential antifungal agents.[1] From the results of the anti-fungal activity it is clearly concluded that the synthesized compounds are promising, great antimicrobial agents.[2] The substituted quinoline moieties are as of now known for diverse organic exercises. Presence of groups like -methoxy group, -Nitrogen Dioxide, -Bromine, -N-CH3, at the different positions of phenyl nucleus and heterocyclic system attached to quinoline nucleus showed excellent antifungal activity. As future prospects the Qd3 compound showed significant antifungal activity and may apparently comparable with the standard drug ketoconazole if it is purified with much better quality and standards.

Keywords: Antifungal agents, quinoline, methoxy group.