An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Syeda Saniya Fatima*, Syeda Wasfiya Noor, Afreen Begum and Imam Pasha Syed


We have synthesized a few novel quinoline analogs combining with distinctive substituted fragrant and hetero cyclic aldehydes ring structure to obtain some better antifungal agents. We have successfully synthesized five derivatives from quinoline compound as qd1, qd2, qd3, qd4, qd5 and thier IUPAC names are. a) N-benzylidene-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)- yl)benzenesulfonamide. b) N-benzylidene-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)-N-(4- methoxybenzylidene) benzenesulfonamide. c) N-benzylidene-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)-yl)-N-(3- methoxybenzylidene) benzenesulfonamide. d) N-(2-hydroxybenzylidene)-4-(7-hydroxy-4-methyl-2-oxoquinolin-1(2H)- yl)benzenesulfonamide. e) N-{2-[(1E)-3-oxoprop-1-en-1-yl]benzylidene}-4-(7-hydroxy-4-methyl-2- oxoquinolin-1(2H)-yl)benzenesulfonamide. This work aims to outline the recent advances in quinolone derivatives showing excellent antifungal activity equipped with conventional drugs. This review covers the recent advances in quinolone derivatives as potential antifungal agents.[1] From the results of the anti-fungal activity it is clearly concluded that the synthesized compounds are promising, great antimicrobial agents.[2] The substituted quinoline moieties are as of now known for diverse organic exercises. Presence of groups like -methoxy group, -Nitrogen Dioxide, -Bromine, -N-CH3, at the different positions of phenyl nucleus and heterocyclic system attached to quinoline nucleus showed excellent antifungal activity. As future prospects the Qd3 compound showed significant antifungal activity and may apparently comparable with the standard drug ketoconazole if it is purified with much better quality and standards.

Keywords: Antifungal agents, quinoline, methoxy group.

[Full Text Article]



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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing