TRANSDERMAL SUSTAINED AND SAFE RELEASE DRUG DELIVERY SYSTEM
Gulafshan Parveen* and Poonam Joshi
Transdermal drug delivery system is most preferable route of drug administration. This route has high acceptability because of safe and effective delivery of drug. The human skin is a readily accessible surface for drug delivery. Skin of an average adult body covers a surface of approximately 2 m2 and receives about one- third of the blood circulating through the body. Over the past decades, developing controlled drug delivery has become increasingly important in the pharmaceutical industry. The human skin surface is known to contain, on an average, 10- 70 hairs follicle and 200-250sweat duct on every square centimeters of the skin area. It is one of the most readily accessible organ of the human body. There is considerable interest in the skin as a site of drug application both for local and systemic effect. However, the skin, in particular the stratum corneum, poses a formidable barrier to drug penetration thereby limiting topical and transdermal bioavailability. Skin penetration enhancement technique have been developed to improve bioavailability and enhance the range of drugs for which topical and transdermal delivery is a viable option. During the past decades, the number of drugs formulated in the patches has hardly enhance, and there has been little change in the composition of the patch system. Modification have been mostly limited to refinement of the material used. The present review article explores the overall study on transdermal drug delivery system which lead to novel drug delivery system.
Keywords: Transdermal drug delivery, permeation enhancer, topical, epidermis.
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