EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

EFFECT OF FOOD ADDITIVES; CARMOISINE AND ACESULFAME POTASSIUM ON THE LIVER OF ADULT WISTAR RAT

Ezejindu D. N., Aguwa U. S.*, Ugwuja J. O., Ezejindu I. O., Akukwu Cyprian D., Uloneme Godwin C., Okafor E. C., Okeke S. M.

ABSTRACT

Carmoisine and acesulfame potassium are widely used as food additives. This study examined the effects of oral administration of carmoisine and acesulfame potassium on some biochemical parameters and histology of the liver of Wistar rats. Twenty adult Wistar rats (average weight 120-200g) were divided into four groups of five animals each. Group A (control) was given rat feed and water, group B received 500mg/kg/bw of carmoisine, group C received 500mg/kg/bw of acesulfame potassium while group D was co-administered 250mg/kg body weight each of carmoisine and acesulfame potassium. All food additives were given daily by oral gavage method for twenty-one days. Twenty-four hours after the last administration, the rats were sacrificed. The liver tissues were harvested, weighed and fixed in 10% formaline for histological studies. Blood for serum chemistry was collected through ocular puncture for histochemical studies from all the rats. Evaluation of liver function enzymes was carried out using randox kit method. The serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), in groups B, C & D were significantly higher (P<0.05) than the control group A. Histological observation showed that administration of carmoisine and acesulfame potassium resulted in necrosis of liver tissue and this correlates with the biochemical results. This study revealed that exposure of rats to carmoisine and acesulfame pottassium at these concentrations caused impaired hepatic functions which may constitute a risk factor for hepatic disorders.

Keywords: Carmoisine, Acesulfame Potassium, Liver, Adult Wistar rat.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing