ANTICANCER EFFECTS OF METHANOL EXTRACT OF LIBYAN SALVIA FRUTICOSA MILL ON MCF7, T47D AND (MDA-MB-468) BREAST CELLS LINES

Salwa I. Eltawaty*, Sanaa O. Yagoub, Samia A. Shouman3, Asim Ahmed4 and Fayza A Omer5

ABSTRACT

Because of the well-known health benefits of the Salvia species plant, this plant has been used globally for traditional medicine for long time. More importantly however many extracts of Salvia species have been exhibited significant in vitro and in vivo anticancer performance on a range of different cancer cell types. This in vitro study as the first one highlighted the anti-proliferative activity of methanol extract of bark of the Libyan Salvia fruticosa on three breast cancer cells lines (MCF-7, T47D and MDA-MD-468) to reveal the potential of this plant species to be used as natural anticancer agent and add new insight for further research of this species of the plant Salvia, specifically. SRB assay was used in this study and the results showed good cytotoxic activity against tested breast cell lines. Conclusion: Our results suggest that polar methanol extract of bark of Salvia fruticosa Mill can produce good therapeutic effect in treatment of breast cancer of MCF-7, T47D and MDA-468 cell lines types and could be considered as the potential source of raw material in pharmaceutical industry for the extraction and isolation of natural compounds with a good spectrum of biological cytotoxic activity in breast malignancy therapy.

Keywords: Anticancer activity, Breast cell lines, Salvia fruticosa Mill, IC50.