EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

AQUEOUS ROOT BARK EXTRACT OF NAUCLEA LATIFOLIA PREVENTS INFLAMMATION AND REDUCES PAIN IN MICE

Etti, Imaobong Christopher*, Akpan, Mary Richard and Akwaowo Mfonobong

ABSTRACT

Nauclea latifolia Smith is a valuable medicinal plant used in the traditional medicine and reported to possess a wide spectrum of medicinal properties. The focus of this study was to evaluate the anti-nociceptive and anti-inflammatory properties of the aqueous root bark extract of Nauclea latifolia, in mice after determining its median lethal dose. The anti-inflammatory activity was investigated using a phlogistic agent (egg albumin) and xylene-induced ear edema, while the anti-nociceptive activity was evaluated using the acetic acid induced mouse writhing and the hot-plate test. These activities were compared to those of a standard, acetylsalicylic acid (100 mg/kg). Nauclea latifolia root bark extract (150, 299 & 449 mg/kg) inhibited xylene-induced ear edema in mice (inhibition ratio: 3.5 %, 27.6 %, and 69.0 %, respectively) and dose dependently decreased the hind paw edema with a percentage inhibition of 10 %, 63 % and 90 % respectively. There was a significant amelioration of acetic acid increased vascular permeability in mice (inhibition ratio: 47.9 %, and 72.0 %) pretreated with 299 & 449 mg/kg of the aqueous root back extract respectively. A significant increase in pain reaction time (17.5s, 44.2s) was observed in animals treated with 299 mg/kg and 449 mg/kg of the extract in the hot-plate test when compared to the control group treated with distilled water whose pain threshold was seen within 7.7 seconds. In each of the different models used, the 449 mg/kg dose of the extract showed a greater anti-inflammatory as well as anti-nociceptive effect than 100 mg/kg of acetylsalicylic acid. The Nauclea latifolia root bark extract if exploited may be a better alternative for the management of pain and inflammation.

Keywords: Nauclea latifolia, phlogistic agent.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing