EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

SELECTED RENAL OXIDATIVE STRESS MARKERS AND LIPID PROFILE CHANGES DUE TO LONG TERM CONSUMPTION OF INSTANT NOODLES IN ADULT WISTAR RATS

Garba Abdullahi, Adjene Josiah Obaghwarhievwo and *Odigie Mike Osagie

ABSTRACT

Reports have linked the levels of renal antioxidant markers to the development of kidney disease. Though the effects of instant noodles consumption on the levels of these markers and serum lipid profile remain vague and poorly established, this study sought to investigate the long term consumption of instant noodles on selected oxidative stress markers and lipid profile levels of Wistar rats. Fifty (50) adult wistar rats of an average weight of 200g were purchased for the study. After fourteen (14) days of acclimatization, the rats were then grouped into five (5) groups of ten (10) rats each. While Group A was fed with cooked instant noodle (Type A), group B received cooked instant noodles mixed with its spice, whereas, group C and D were respectively fed with cooked instant noodles (type B) and type B with spice. Lastly, group E (Control) rats received standard rat chow and the other animals were given water ad libitum. At the end of administration of test substances, rats were sacrificed (by cervical dislocation) and kidney tissue harvested and homogenized for assay of selected oxidative stress markers [Catalase, Malonyldialdehyde (MDA), Glutathione Peroxidase (GPx) and superoxide Dismutase (SOD)]. Blood sample was also collected and subjected to biochemical analysis of various levels of lipid profile [Triglycerides (TG) Total Cholesterol (TC), High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL)]. After data collation, result showed a statistically insignificant increase (p < 0.05) in serum lipid levels of all treated animals as against those of the control group. Renal antioxidant enzyme levels, we observed a statistically significant (p < 0.05) decrease in Catalase, SOD and GPx concentrations in the treatment group. However there was a significant (p < 0.05) increase in MDA levels in the treatment groups as compared with control, which was a strong indication that renal cortical structures were compromised. Study also observed a statistically significant (p < 0.05) increase in all assayed lipid profiles levels. We strongly recommend further studies aimed at corroborating these findings.

Keywords: Kidney, Instant Noodles, Lipid profile, Oxidative stress markers.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing