STUDY OF EFFECT OF STERCULIA FOETIDA LINN.(STERCULIACEAE) SEEDS ON INSULIN RESISTANCE IN TYPE II DIABETES MELLITUS IN RATS

*Hemalata Dange and Dr. Pramod Ingale

ABSTRACT

Diabetes prevalence is increasing at an accelerating rate approaching epidemic levels. Type II Diabetes is heterogeneous, progressive disorder initially characterized by glucose intolerance and compensatory hyperinsulinaemia which in later stages progress to insulin resistance and impaired beta cell function. Type II Diabetes which accounts for 90-95% of diabetic cases is largely caused by social and Lifestyle that can be readily controlled. Obesity is one of the major factors which contribute in development of Diabetes Mellitus.[1] Obesity leads to an increase in the adipose tissue mass. This in turn triggers insulin Resistance in fat, skeletal muscle and liver leading to Type II Diabetes Mellitus. Current research is focused on the development of newer drug leads from phytoconstituents of medicinal plants which have been used in traditional practices, so as to get more potential and effective agents with lesser side effects than existing agents.[3]

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