SYNTHESIS OF SOME DIPEPTIDES CONTAINING HETEROCYCLE ISO-NICOTINIC ACID AS AN ANTIMICROBIAL AGENT

Khushi Dethe* and Kundan Tiwari

ABSTRACT

Proteins and peptides are continued to grow in medications for their potential use in current drug therapy and in protein drug market. The Peptide based drugs are use to cure cancer as well as antimicrobial agent. Most of the synthetic molecules have been design to prevent cell proliferation, Multiplication of microbial cells. Most of the peptide when attach to heterocyclic compounds shows most of the activity like antimicrobial activity, antifungal, antiemetics etc. The wide varieties of biopeptides have been discovered from last two decades. Condensation of heterocyclic moiety viz nicotinic acid, thiazole, coumarin, quinoline, furan, imidazole etc with peptides containing amino acids shows potent biological activities.

Keywords: Coumarin, furan, imidazole, nicotinic acid, quinoline, thiazole.