Q ABSORBANCE METHOD FOR SIMULTANEOUS DETERMINATION OF PARACETAMOL AND ORPHENADRINE CITRATE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORMS

Mahmoud M. Sebaiy* and Amr A. Mattar

ABSTRACT

A simple, specific, accurate and precise spectrophotometric method was settled for simultaneous determination of paracetamol and orphenadrine citrate in their pure form and in pharmaceutical formulation. Q Absorbance has been used in simultaneous determination of both drugs without prior separation. Q Absorbance method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits. Advantages and disadvantages of Q Absorbance were discussed and statistical comparison between the proposed method and the reference method was performed.

Keywords: Spectrophotometric; Paracetamol; Orphenadrine citrate; Q Absorbance; ICH guidelines.