COMPARATIVE STUDY OF LOSARTAN POTASSIUM WITH MARKETED MATRIX TABLET AS CONTROLLED RELEASE

Rina G. Maskare*, Nitin H. Indurwade and Vijaya Patle

ABSTRACT

The objective of the present study was to develop hydrophilic polymer and hydrophobic polymer based matrix Losartan potassium controlled release tablets which can release the drug up to time of 12 hrs in predetermined rate using 32 factorial design. The CR (controlled release) tablets of Losartan potassium were prepared employing different concentrations of HPMC K100 and ethyl cellulose in different combinations as rate retardants by Direct Compression technique. Statistical elucidations of polynomials were established for all the responses. The formulations were evaluated for pre compression and post compression parameters. The results demonstrated the effectiveness of the proposed design for development of Losartan potassium sustained release tablets with optimized properties. The formulation was fabricated with a very less polymer ratio and show a very a good release profile at the end of 20th hours.

Keywords: Losartan Potassium, Controlled Release, 32 Factorial Design, direct compression.