EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ANTIDIABETIC ACTIVITY OF COCCINTIA GRANDIS IN ALLOXAN INDUCED DIABETIC RATS

Shubham G. Suryawanshi*, Kalyani R. Shinde, Prof. P. N. Folane, Prof. S. L. Khedekar and Prof. S. D. Sagrule

ABSTRACT

Diabetes mellitus is lifestyle disease rapidly spreading in India. It has been major health issue in south-east Asia and world’s largest numbers of diabetics are found in India. By 2019, 60.8 million diabetics arefound and this will rise up to 97 million by 2030. Therefore looking at the scenario and possible complications of uncontrolled B.G.L, different modes of therapy have been practiced. The present work is an effort to study Antidiabetic’s activity of coccintia grandis in alloxan induced diabetic rats. Coccintia grandis is commonly known as Gram (ivy gourd. Family- CCucurbitaece). A single dose of (150 mg/kg) alloxan prepared in normal saline solution was injected intraperitonially to induce diabetes in rats. The age matched control rats receives an equal volume of citrate buffer and used along with diabetic animals. Diabetes was confirmed after 48 hr of alloxan injection.The rats having plasma glucose level more than 300 mg/dl were selected and study was conducted for 21 days. The rats were divided into six groups and serum glucose levels were assessed by GOD - PAP method. The BGL and body weights were taken at day 1, day 3, day 7 and day 21.This investigation proves that coccintia grandis shows beneficial effect in diabetes. It is found to reduce the BGL and prevented loss of Body weight in diabetic rats and does not have any effect on normal glycemic level. Thus, it can be concluded that coccintia grandis can be used as supportive therapy for diabetes mellitus.

Keywords: Alloxan, Antidiabetic, 5% Glucose, Metformin, Ethanol.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database