ACUTE TOXICITY STUDIES OF EDIBLE OIL EXTRACTED FROM INDIGENOUS SEEDS
Kiran A. Suryavanshi*, Dr. Yogesh V. Ushir and Dr. Venkat Chellam
Now a days ayurvedic dosage forms are preferred over allopathic. So for the safer use these plants and its preparations need to be evaluated for their toxicity. The main aim of this study was to test the acute toxicity of natural oils extracted from indigenously edible such as Buchanania lanzan spreng. belonging to family Anacardiaceae, commonly known as Chironji in Hindi, Buchanania lanzan spreng is a tree of 12-15 mt high, with straight trunk, and Simmondsia chinesis., belonging to family from Simmondsiacea commonly known as Jojoba in Hindi is a large, evergreen, forest tree more than 30 mt in height a tree. These two plants are easily available and their various parts are used in treatment of various diseases traditionally. The acute toxicity study was studied on Swiss mice with a dose of 2 g/Kg body weight orally. The single administration exposure of the seed oil on Swiss mice was carried out and the exposure route was oral with water as a vehicle. The observations of changes in body weight, food and water intake as well as cage side observations were reported. The plants were found to be nontoxic as no mortality was recorded even at the highest dose level.
Keywords: Ayurvedic, Toxicity, Natural oil.
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