EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

SYNTHESIS, EVALUATION AND MOLECULAR DOCKING OF SULPHONAMIDE/ISOTHIOCYANATE LINKED QUINAZOLINONE DERIVATIVES AS ANTIDIABETIC ACTIVITY

Pournima A. Bhalekar* and Shailaja B. Jadhav

ABSTRACT

A series of Quinazolinone linked sulphonamide and isothiocynates derivatives was designed synthesized and evaluated for type 2 diabeties study. Designed compound were docked using AutoDock tool software with DPP-IV inhibitor protein (PDB: 3OPM). And the good dock score compounds is synthesized and evaluated for antidiabetic study in STZ- Nicotinamide model of wistar rats. Amongst all the compounds designed in the study we identified compounds A3 and C6 as potent, selective and orally active agents.

Keywords: Quinazolinone, Sulphonamide, Isothiocyanate, Type 2 diabeties, Molecular Docking, STZNicotinamide model.


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SJIF Impact Factor: 7.065

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