SYNTHESIS, EVALUATION AND MOLECULAR DOCKING OF SULPHONAMIDE/ISOTHIOCYANATE LINKED QUINAZOLINONE DERIVATIVES AS ANTIDIABETIC ACTIVITY
Pournima A. Bhalekar* and Shailaja B. Jadhav
A series of Quinazolinone linked sulphonamide and isothiocynates derivatives was designed synthesized and
evaluated for type 2 diabeties study. Designed compound were docked using AutoDock tool software with DPP-IV
inhibitor protein (PDB: 3OPM). And the good dock score compounds is synthesized and evaluated for antidiabetic
study in STZ- Nicotinamide model of wistar rats. Amongst all the compounds designed in the study we identified
compounds A3 and C6 as potent, selective and orally active agents.
Keywords: Quinazolinone, Sulphonamide, Isothiocyanate, Type 2 diabeties, Molecular Docking, STZNicotinamide model.
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