EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

FORMULATION AND EVALUATION OF VORICONAZOLE TRANSFEROSOMAL GEL

Pravallika T.*, Dr. P. Prasuna Sundari, Dr. M. Bhagavan Raju

ABSTRACT

The aim of this research work is to develop voriconazole Transferosomal gel for better transdermal permeation and to produce sustained release of drug for local antifungal activity. Voriconazole is a triazole antifungal drug. It is used orally and intravenously. Formulation of voriconazole as transferosomal gel reduces dose dumping and increases therapeutic efficacy. Transferosomes are appropriate delivery system for skin. They are ultra-deformable vesicles. Voriconazole transferosomes were prepared by Thin Film Hydration method using Phosphatidylcholine and Edge Activators in different ratios. The edge activators used in the formulation are Span 60, Span 80 and Tween 80. The prepared transferosomes were evaluated for entrapment efficiency, drug content and in vitro drug release. Formulation F3 containing phosphatidylcholine (85mg) and Span 60 (15mg) was selected based on entrapment efficiency and drug release. Entrapment efficiency and drug release was 87.62±0.26 and 82.52±0.35. The selected formulation shows Zeta potential of -57.7mV and vesicle size of 597.4nm. The selected formulation F3 was incorporated into gel using Carbopol 934 of different concentrations. Formulated gels were evaluated for visual appearance, pH, drug content and In vitro diffusion studies. The selected transferosomal gel of voriconazole shows pH value 6.7, drug content 91.56 and drug release percentage 79.54.

Keywords: Transferosomes, voriconazole, phosphatidylcholine, Edge Activator, Carbopol 934.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia