EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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Abstract

AN OBSERVATIONAL STUDY OF EFFECT OF ESMOLOL ON ATTENUATION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND INTUBATION

Dr. Prakash Dhumal, *Dr. Saee Gosavi and Dr. Deviprasad Shivade

ABSTRACT

Introduction: Endotracheal intubation and laryngoscopy provides an intense noxious stimulus via vagal and glossopharyngeal afferents that result in a reflex autonomic activation, which is usually manifested as hypertension and tachycardia. This reflex is termed as pressor response. Esmolol possesses several properties to attenuate this response. Primary objective- to study the effect of 0.4mg/kg esmolol on attenuation of pressor response Secondary objective- assess hemodynamic changes during laryngoscopy and intubation. Methods: After institutional review, board approval and written informed consent, 62 patients with ASA physical status I-II aged 18-50 years to undergo elective surgery under general anaesthesia were studied. Patients with known allergies, hypertension ,diabetes, heart blocks, ischemic heart disease, brain disease and baseline HR<60 and SBP<100 were excluded. Patients were randomly divided into two groups, group E received injection Esmolol 0.4mg/kg and group C received normal saline 3min before intubation. All hemodynamic changes were monitored at baseline, before induction, before intubation and after intubation. Observation and results: The differences in parameters was statistically significant. The rise in heart rate 30sec after intubation was more in group C than group E. The blood pressure, mean arterial pressure and rate pressure product were more in group C than group E after intubation. No significant ECG changes were seen in both groups. Conclusions: This study confirmed that there is significant increase in hemodynamic variables on laryngoscopy and intubation and concludes that esmolol in low dose attenuates pressor response to some extent.

Keywords: .


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia